VARYING INFLUENCE OF TUBERCULOUS RABBIT PLASMA ON THE GROWTH OF FIBROBLASTS IN VITRO

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Abstract
The plasma from rabbits with early tuberculosis had a growth inhibiting effect on fibroblasts in vitro; that from late tuberculosis was growth stimulating. The rabbits were of a single breed, were infected with a small dose of tubercle bacilli and usually developed a chronic stage of the disease. It is thought the excess of lipoids in the early cases had the depressing effect. The lipoid granules were picked up by fibroblasts. The later stimulating effect is believed due to leucocytes which are increased in rabbits with the late stage.

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