Mutagenic Properties of Nitrosated Spermidine
- 1 May 1978
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 158 (1) , 85-88
- https://doi.org/10.3181/00379727-158-40145
Abstract
The nitrosation of spermidine results in direct-acting mutagens as shown by the Ames assay utilizing Salmonella typhimurium TA1535. The mutagenic effect is catalyzed by thiocyanate and inhibited by ascorbic acid. The reaction takes place at pH ranges 3.0-6.0. The possibility that this reaction may play a role in human gastric cancer etiology is discussed.This publication has 1 reference indexed in Scilit:
- Gastric Cancer in Colombia. I. Cancer Risk and Suspect Environmental Agents2JNCI Journal of the National Cancer Institute, 1976