Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors
- 21 November 2005
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 14 (7) , 2162-2177
- https://doi.org/10.1016/j.bmc.2005.11.005
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- Structure based design of a series of potent and selective non peptidic PTP-1B inhibitorsBioorganic & Medicinal Chemistry Letters, 2004
- The development of potent non-peptidic PTP-1B inhibitorsBioorganic & Medicinal Chemistry Letters, 2004
- Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing LigandsJournal of Medicinal Chemistry, 2003
- Modification of the N-terminus of peptidomimetic protein tyrosine phosphatase 1B (PTP1B) inhibitors: identification of analogues with cellular activityBioorganic & Medicinal Chemistry Letters, 2003
- Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob MiceDiabetes, 2003
- Protein tyrosine phosphatase 1B inhibitors for diabetesNature Reviews Drug Discovery, 2002
- Discovery and SAR of a Novel Selective and Orally Bioavailable Nonpeptide Classical Competitive Inhibitor Class of Protein-Tyrosine Phosphatase 1BJournal of Medicinal Chemistry, 2002
- PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic miceProceedings of the National Academy of Sciences, 2002
- Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient MiceMolecular and Cellular Biology, 2000
- Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B GeneScience, 1999