PREDICTIVE TESTS FOR THE RESPONSE TO CANCER-CHEMOTHERAPY - LIMITATIONS RELATED TO THE PREDICTION OF RARE EVENTS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 68  (4) , 611-613
Abstract
The reliability of a predictive test may be characterized by its sensitivity and specificity. The probability that a predicted event will actually occur depends on these indexes as well as the frequency of the predicted event. If such a test is used to predict for the therapeutic effect of single-agent chemotherapy in cancer patients, its predictive value is markedly affected by a generally low therapeutic efficacy in an unselected population.

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