In situ radiolysis electron spin resonance study of the radical-anions of substituted nitroimidazoles and nitroaromatic compounds
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Faraday Transactions 1: Physical Chemistry in Condensed Phases
- Vol. 74, 511-518
- https://doi.org/10.1039/f19787400511
Abstract
Reaction of e– aq, (CH3)2ĊOH, (CH3)2CO[graphic omitted] or CO[graphic omitted] 2 with a number of substituted nitroimidazoles and nitrobenzenes results in the formation of their radical-anions and in no case were radical-adducts detected. Changes in the e.s.r. spectra of the product species with pH are interpreted in terms of either the protonation of the radical-anion (metronidazole) or the loss of a proton from the radical anion (2-methyl-5-nitroimidazole, 4-nitroimidazole and nitrophenols) and pK values of some of these processes are evaluated. In several cases the dynamics of these acid–base reactions influence the linewidths of the e.s.r. spectra.Keywords
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