New derivatization for liquid chromatographic resolution of amino acid enantiomers.

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Abstract
A new method for liquid chromatographic resolution of amino acid enantiomers by the formation of diastereomers was developed. A chiral reagent used for this purpose, (-)-.alpha.-methoxy-.alpha.-methyl-1-naphthaleneacetic acid (IIb), was readily prepared by fractionally crystallizing the (+)-.alpha.-methylbenzylamine salt. The diastereomers formed from amino acid methyl esters and IIb by the N,N''-dicyclohexylcarbodiimide method were efficiently resolved on the normal phase column.

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