Cellular Swelling

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Abstract
Cellular volume is maintained by an active energy-requiring process of the cell. Hypothermia, hypoxia or other metabolic deprivations produce an increase in cellular volume that is readily observed in surviving tissue slices in vitro. Reduction of oxygen concentration to 5% was required to produce significant cell swelling at 7[degree]C. At 20% or less oxygen concentration, there was no significant hypothermic swelling effect. [Low molecular weight dextran] LMWD exerts a marked colloidal osmotic effect on in vitro tissues with reversal of hypothermic cellular swelling.