Antigenic similarities among mammalian immunoglobulins.
- 1 August 1972
- journal article
- Vol. 23 (2) , 137-45
Abstract
Cross-reactions between immunoglobulins from twelve mammalian species were observed by immunoelectrophoresis with antisera prepared in rabbits against the purified IgG of each species. The Fc fragments of the IgG from man, pig, goat, sheep and cow were compared by examination of the cross-reactions before and after absorption of the antisera with the various IgG. Eight antigenic determinants could be detected; some of them were species-specific, others were shared by IgG from two or more species. A close resemblance was found between goat, sheep and cow IgG.This publication has 8 references indexed in Scilit:
- Immunological activity of cytochrome c. I. Precipitating antibodies to monomeric vertebrate cytochromes c.1970
- Phylogenetic insight into evolution of mammalian Fc fragment of gamma G globulin using staphylococcal protein A.1970
- The specificity of the reactions of rheumatoid factors with different conformational forms of gamma-G-globulins of various species of origin.1969
- Quantitative Immunochemistry and the Evolution of Primate Albumins: Micro-Complement FixationScience, 1966
- THE EVOLUTIONARY ORIGINS OF THE IMMUNOGLOBULINSProceedings of the National Academy of Sciences, 1966
- Antibody Active Sites and Immunoglobulin MoleculesScience, 1966
- Antigenic Correspondence of Serum Albumins among the PrimatesScience, 1966
- Separation and Isolation of Fractions of Rabbit Gamma-Globulin containing the Antibody and Antigenic Combining SitesNature, 1958