Asymmetric intercoenzyme hydrogen transfer between NADH model compounds and flavins

Abstract
A chiral flavin [(S)-3-methyl-10-(1′-hydroxy-3′-methylbutane-2′-yl)isoalloxazine, (1b)] has been synthesised: hydrogen transfer to (1b) and tetra(O-acetyl)riboflavin from chiral NADH model compounds occurred in an asymmetric manner only in the presence of high concentrations of Mg(ClO4)2.

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