Synthesis and Binding Activity of 3- and 4-Deoxy-N-Acetyl-Galactosamine Derivatives
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 9 (5) , 707-719
- https://doi.org/10.1080/07328309008543865
Abstract
Allyl 3- and 4-deoxy-N-acetyl-β-D-galactosaminides were synthesized from galactosamine and glucosamine, respectively. Using inhibition assay, we found that neither the 3-deoxy nor the 4-deoxy derivative had any binding affinity to the Gal/GalNAc lectins of rabbit and rat liver at the highest concentration tested (40 mM), indicating that the absence of either 3- or 4-hydroxyl group of N-acetyl-galactosamine (GalNAc) caused a decreace in afffinity of at least 100-fold. Therefore, both 3- and 4-hydroxyl groups of GalNAc are required for the binding to the mammalian hepatic lectins.This publication has 16 references indexed in Scilit:
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