Oxygen Affinity and Acid-Base Status of Human Blood during Exposure to Hypoxia and Carbon Monoxide
- 1 January 1968
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 21 (sup103) , 9-15
- https://doi.org/10.1080/00365516809168026
Abstract
In eight subjects exposed to hypoxia at high altitude the oxyhemoglobin dissociation curve was shifted to the right, the half saturation oxygen tension at pH 7.40 being changed from 26.7 to 30.2 mm Hg on the average. The decreased affinity of hemoglobin for oxygen appeared within 12 hours after exposure to hypoxia. The shift was confirmed in short exposure experiments using simulated high altitude in a low pressure chamber. At prolonged carbon monoxide exposure the expected shift of the oxygen dissociation curve to the left occurred, but no adaptive changes were found. The physiological implication of these differences are discussed. It is suggested that the rapid shift to the right at high altitude may be a physiological regulation.Keywords
This publication has 26 references indexed in Scilit:
- Introduction and General Description of the Study and of the Procedures for Prolonged Exposure to Carbon Monoxide and HypoxiaScandinavian Journal of Clinical and Laboratory Investigation, 1968
- The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobinBiochemical and Biophysical Research Communications, 1967
- Oxygen Affinity of Hemoglobin in Patients with Cardiovascular Diseases, Anemia, and Cirrhosis of the LiverScandinavian Journal of Clinical and Laboratory Investigation, 1967
- Photometric Determination of Oxyhemoglobin Saturation in the Presence of Carbon Monoxide Hemoglobin, Especially at Low Oxygen TensionsScandinavian Journal of Clinical and Laboratory Investigation, 1966
- The Influence of Temperature and Ph on the Dissociation Curve of Oxyhemoglobin of Human BloodScandinavian Journal of Clinical and Laboratory Investigation, 1965
- The influence of some factors of the red blood cells on the oxygen-binding capacity of haemoglobinClinica Chimica Acta; International Journal of Clinical Chemistry, 1960
- The Oxygen Dissociation Curve in Anemia Of Various Types1Journal of Clinical Investigation, 1954
- RESPIRATORY PROPERTIES OF THE ARTERIAL BLOOD IN NORMAL MAN AND IN PATIENTS WITH DISEASE OF THE LIVER: POSITION OF THE OXYGEN DISSOCIATION CURVEJournal of Clinical Investigation, 1938
- Adaptations of Mammals to High AltitudesJournal of Mammalogy, 1937
- VIII.—Observations upon the effect of high altitude on the physiological processes of the human body, carried out in the Peruvian Andes, chiefly at Carro de Pasco. - Report to the Peru High-Altitude CommitteePhilosophical Transactions of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1923