Abstract
The report by Ross et al. (1) in the February 16, 2000, issue of the Journal concludes that a combination of estrogen and progestin increases the risk of breast cancer over time when compared with estrogen alone. A similar conclusion was recently reported in a paper in the Journal of the American Medical Association by Schairer et al. (2). There is little question that hormone therapy, either estrogen or estrogen/progestin, is associated with an increased risk of breast cancer especially with long-term use (3). However, papers contrasting estrogen therapy with estrogen/progestin therapy have a serious use bias.

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