Summary An analysis of the lipids of various organs of an 11-month-old female dying of Farber's Disease indicated a marked increase in ceramide varying from 8 times normal in the kidney to 66 times normal in the liver. Ceramide made up 13% of the liver lipids. There was also a slight increase in other lipids in the liver, but aside from the ceramide, only the gangliosides were increased in all organs tested. The increased ganglioside was more marked in subcutaneous nodule and varied proportionally with the number of foam cells seen in the tissue. The mechanism by which these lipids are stored in Farber's Disease remains to be determined.