ABO Hemolytic Disease of the Newborn: Evaluation of Management and Identification of Racial and Antigenic Factors

Abstract
Data from 16,320 deliveries from two time periods were examined to compare the incidence of positive direct Coombs' tests and the number of exchange transfusions performed, using different methods of screening and treatment in each time period. Early routine screening revealed an eightfold increase in the number of Coombs-positive infants, while the combined effect of instituting early screening and the change from white light to special blue light phototherapy greatly diminished the number of exchange transfusions.

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