2 AGAROSE ELECTROPHORETIC SYSTEMS FOR DEMONSTRATION OF OLIGOCLONAL BANDS IN CEREBROSPINAL-FLUID COMPARED

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 26  (2) , 343-345
Abstract
Demonstration of oligoclonal bands by [human] CSF electrophoresis is an important aid in establishing a diagnosis of multiple sclerosis. Electrophoretic systems vary in their diagnostic effectiveness. Two systems are compared in this respect. For a thin-layer agarose system, sensitivity was less (47%) than for a high-resolution agarose system (87%). Each system had good specificity (92 and 85%, respectively). Interpretation of electrophoretic patterns for CSF should be available in clinical laboratories. The best available system should be used for demonstration of oligoclonal bands.

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