The ATP switch model for ABC transporters
Top Cited Papers
- 27 September 2004
- journal article
- review article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 11 (10) , 918-926
- https://doi.org/10.1038/nsmb836
Abstract
ABC transporters mediate active translocation of a diverse range of molecules across all cell membranes. They comprise two nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). Recent biochemical, structural and genetic studies have led to the ATP-switch model in which ATP binding and ATP hydrolysis, respectively, induce formation and dissociation of an NBD dimer. This provides an exquisitely regulated switch that induces conformational changes in the TMDs to mediate membrane transport.Keywords
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