Serum ferritin level. Determinant of iron requirement in hemodialysis patients

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Abstract
Patients (17) without renal failure and 14 patients receiving long-term hemodialysis were studied. Serum and bone marrow ferritin determinations were made at the time of bone marrow aspiration. A good correlation was found between serum ferritin levels and bone marrow Fe stores, as well as between bone marrow ferritin levels and Fe stores. Serum ferritin determinations gave an accurate estimation of bone marrow Fe stores, thereby providing a reliable guide for Fe replacement therapy and reducing the need for repeated bone marrow aspirations. Serum ferritin levels of less than 105 ng/ml suggest decreased Fe stores and values greater than 120 ng/ml indicated adequate or increased Fe stores. Bone marrow ferritin determinations may be useful in quantitating bone marrow Fe stores.

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