Ly and la phenotype of suppressor T cells induced by graft‐vs. ‐host reaction
- 1 October 1977
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 7 (10) , 746-748
- https://doi.org/10.1002/eji.1830071019
Abstract
Suppressor T cells were generated in (CBA x C57BL)F1 mice undergoing graf t-vs. -host (GvH) reaction and treated with anti-Ly and anti-Ia antisera to determine their membrane antigen phenotype. Pretreatment of CBA-induced GvH suppressor T cells with anti-Ly-1.1, anti-Ly-2.1 or anti-Iak anti-sera plus complement abrogated their suppressive properties when tested against primed F1 spleen cells in vitro. In contrast, concanavalin A (Con A)-induced suppressor T cells were insensitive to anti-Ly-1.1 serum. It is concluded that GvH-induced suppressor T cells are Ly-1+,2+,3+,Ia+, and thus distinct from Con A or antigen-induced suppressor T cells.This publication has 7 references indexed in Scilit:
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