Expression of Major Histocompatibility Complex Class II Subregion Products by Jejunal Epithelium in Patients with Coeliac Disease
- 1 November 1987
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 26 (5) , 563-571
- https://doi.org/10.1111/j.1365-3083.1987.tb02290.x
Abstract
The MHC class II subregion product (HLA-DR), HLA-DP, and HLA-DQ) were located by immunofluorescence in serial sections of ethanol-fixed, paraffin-embedded jejunal mucosa from control subjects and patients with coeliac disease (CD). DR staining was seen in a granular luminal distribution and basolaterally on surface epithelial was positive for DR almost to the bottom of the glands. This contrasted with virtually absent glandular DR standing in controls and weak staining including only the upper part of the crypts in 5 out of 11 treated patients. HLA-DQ appeared only in three untreated patients and was restricted to patches of surface epithelium. The number of intraepithelial T lymphocytes per millimetre of surface epithelium was significantly higher in untreated than in treated CD patients or controls; it was also significantly higher in specimens with epithelial DP expression than in those without. This suggested that intraepithelial lymphocytes modulate epithelial class II expression.This publication has 38 references indexed in Scilit:
- Subcellular Localization of Class I (A,B,C) and Class II (DR and DQ) MHC Antigens in Jejunal Epithelium of Children with Coeliac DiseaseJournal of Pediatric Gastroenterology and Nutrition, 1987
- Review: Class II molecules of the major histocompatibility complex considered as differentiation markersHuman Immunology, 1986
- A radioimmunoassay typing study of non-DQw2-associated celiac diseaseClinical Immunology and Immunopathology, 1986
- Gene products of the HLA-D region in normal and malignant tissues of nonlymphoid originHuman Immunology, 1986
- Epithelial MHC class II sub-region expression in autoimmunityImmunology Today, 1986
- ASHI workshop summary report of the Science and Education Subcommittee: Structural and functional relationships of human class II MHC moleculesHuman Immunology, 1986
- Lectin activity of gluten identified as wheat germ agglutininBiochemical and Biophysical Research Communications, 1985
- The Human Gastrointestinal Secretory Immune System in Health and DiseaseScandinavian Journal of Gastroenterology, 1985
- Characterization and expression of the HLA-DC antigens defined by anti-Leu 10Human Immunology, 1984
- Evidence that celiac disease is primarily associated with a DC locus allelic specificityClinical Immunology and Immunopathology, 1983