Reduction of digoxin-induced inotropism during quinidine administration

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Abstract
A kinetic and dynamic study of digoxin was performed in 6 healthy human subjects, and repeated in the same subjects after administration of quinidine for 1 wk. Myocardial performance evaluated by systolic time intervals increased in parallel with plasma digoxin concentration, but left ventricular end-diastolic diameter on echocardiography and arterial blood pressure remained constant. The positive inotropic effect of digoxin was abolished during concomitant treatment with quinidine. Quinidine was reported to increase the risk of digitoxicity and the treatment with digoxin and quinidine in combination should be reconsidered.

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