Activity of Azithromycin (CP-62,993) and Erythromycin against Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium Falciparum in Vitro
- 1 September 1992
- journal article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 47 (3) , 378-382
- https://doi.org/10.4269/ajtmh.1992.47.378
Abstract
Several antibiotics, including the macrolide erythromycin and the azalides azithromycin (CP-62,993) and CP-63,956, that inhibit protein synthesis on 70S ribosomes demonstrated antimalarial effects in vitro against two strains of Plasmodium falciparum, one sensitive to chloroquine and the other resistant. In 48-hr incubations, erythromycin was 10-fold less potent than the azalides against the chloroquine-resistant strain. Erythromycin and the azalides were essentially equipotent against the chloroquine-sensitive strain. An additive effect occurred with the azalides in combination with chloroquine against both strains, but this was not seen with erythromycin.Keywords
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