(±)-Dinorpenicillin-2-spirocycloalkane
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 46-47
- https://doi.org/10.1039/c39780000046
Abstract
(±)-Dinorpenicillin-2-spirocycloalkanes have been synthesized, and no change in inhibitory activity of Staphylococcus aureus transpeptidase has been observed; decrease in antibacterial activity occurring with larger spirocycles is interpreted in terms of unsuitable lipophilicity, impairing penetrability through the bacterial cell wall.This publication has 0 references indexed in Scilit: