Estrogen‐receptor binding: Relationship to estrogen‐induced responses
- 1 March 1976
- journal article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 1 (4) , 561-586
- https://doi.org/10.1080/15287397609529359
Abstract
The relationship between nuclear binding of the receptor-estrogen complex (R-E) and estrogenic responses was examined. Nuclear-bound R-E was measured by the [3H] estradiol exchange assay, which permits the quantification of R-E as a function of either endogenous or non labeled estrogen. The quantity of nuclear R-E fluctuated as a function of blood levels of estrogen during the estrous cycle in the rat. This indicates that the accumulation of the R-E complex by the nucleus of uterine cells may be of physiologic significance and under the control of endogenous estrogen.Keywords
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