Histochemical Patterns in Single Peripheral Nerve Fibers
- 1 December 1968
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 19 (6) , 613-617
- https://doi.org/10.1001/archneur.1968.00480060083010
Abstract
THE EXAMINATION of single nerve fibers in teased preparations has contributed to the study of peripheral nerve lesions both in man1-3and in experimental animals.4-10This technique has proved to be particularly suitable for demonstrating segmental demyelination where the early stages of myelin destruction, beginning at the nodes of Ranvier, and the late stages of remyelination, can be studied in greater detail than with any other method of preparation at the light microscope level.11Although the techniques currently available for staining single fibers, using osmium tetroxide or one of the sudan dyes, are excellent for detecting early changes in the myelin sheath, they provide only limited and indirect information about the behavior of the Schwann cell or of the axon. In view of the importance of the Schwann cell in the formation and maintenance of the myelin and the implication that it is the primaryKeywords
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