Swelling of Liver Mitochondria from Rats Fed Diets Deficient in Essential Fatty Acids.

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Abstract
Summary Comparison of rates of in vitro swelling of liver mitochondria from control rats and from rats fed diets deficient in essential fatty acids were studied under a variety of conditions. Higher swelling rates of EFA deficient mitochondria were observed using 0.30 M sucrose medium. Addition of ATP or serum albumin inhibited swelling of normal but not that of EFA deficient mitochondria. Respiratory inhibitors prevented swelling of both groups of mitochondria. Cholate accentuated the swelling pattern of mitochondria from both groups of rats. The fatty acid composition of lipid from mitochondrial, microsomal and supernatant fractions from both groups of livers were also presented.