Bactericidal/Permeability-Increasing Protein Is Expressed by Human Dermal Fibroblasts and Upregulated by Interleukin 4
Open Access
- 1 May 2003
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 10 (3) , 473-475
- https://doi.org/10.1128/cdli.10.3.473-475.2003
Abstract
The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.Keywords
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