Modernization of Nose-Only Smoking Machines for Use in Animal Inhalation Studies

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Abstract
Several modifications to a continuous-smoking inhalation machine for exposing animals to cigarette smoke are described. The improvements to the original machine provide a much more efficient method of exposing animals to cigarette smoke, and improve substantially the simplicity of operation and maintenance. The changes include a simplified pump for extracting puffs from the cigarettes, computerized control and display of exposure conditions, improved structure of the cigarette holders, and addition of a second puffing port to allow preignition of the cigarettes. The modifications were part of an overall modernization of the original design, as well as to allow the use of cigarettes which do not decrease in length as they are smoked (cigarettes which heat rather than burn tobacco).