Studies on the Hypercoagulable State

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Abstract
The intravenous injection of fibrinogen was associated with a prolonged hyperfibrinogenemia in the rabbit, out of proportion to the amount of fibrinogen administered. Factors V, II, VII and X activities were found to be elevated in the plasma simultaneously. A similar pattern of changes was observed in the rabbit after the recovery period from thrombin-induced defibrination. Based on the observations reported here, it was suggested that some fibrinogen or fibrin break-down products deliver the stimulatory message to the liver for increased fibrinogen production. The possible relationship between these observations and hypercoagulable state has been discussed.

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