XENOGENEIC-RESISTANCE TO RAT BONE-MARROW TRANSPLANTATION .3. MATURATION AGE, AND ABROGATION WITH CYCLOPHOSPHAMIDE, CORYNEBACTERIUM-PARVUM AND FRACTIONATED IRRADIATION

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 24  (1) , 20-25
Abstract
Lethally irradiated C57 Bl/6 mice and (C57 .times. A)F1 hybrids fail to accept doses of rat bone marrow cells (5 .times. 106) which give confluent splenic repopulation in non-resistant strains of mice. This phenomenon was termed xenogeneic resistance (XR). XR in (C57 .times. A)F1 mice can be overridden by a very large inoculum of rat bone marrow (26 .times. 106 cells). XR is not manifest in mice of a resistant strain at ages of 18 days or younger, but is manifest at ages of 22 days and older. XR can be abrogated by the following agents: cyclophosphamide, which abrogates XR in a dose dependent manner when given 1 h prior to lethal irradiation and bone marrow transplantation; C. parvum, which abrogates resistance when given 7 days prior to lethal irradiation and bone marrow transplantation; and fractionated irradiation, which, while capable of abrogating XR, is much less potent than either cyclophosphamide or C. parvum.