Work in progress. Gastrointestinal ulcerations: detection using a technetium-99m-labeled ulcer-avid agent.

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Abstract
99mTc-labeled sucralfate, an ulcer-avid material, was shown in preliminary animal and human studies to be stable in vivo with good sensitivity. Eight experimentally produced discrete gastric ulcers in 3 rabbits were visualized using this material. Of 7 human studies, 4 studies were true-positive and 3 were true-negative. 99mTc-labeled sucralfate may prove to have significant clinical advantages for the evaluation of gastrointestinal ulcer disease and other diseases that are associated with loss of mucosal integrity. The method for labeling sucralfate with 99mTc was developed by the authors.