Angiotensinogen Is Related to the Antitrypsin-Antithrombin-Ovalbumin Family
- 28 October 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 222 (4622) , 417-419
- https://doi.org/10.1126/science.6604942
Abstract
The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.This publication has 13 references indexed in Scilit:
- Isolation and sequence characterization of a cDNA clone of human antithrombin III.Proceedings of the National Academy of Sciences, 1983
- Structure and variation of human α1–antitrypsinNature, 1982
- A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology, 1982
- Similar Amino Acid Sequences: Chance or Common Ancestry?Science, 1981
- A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha1-proteinase inhibitorBiochemical and Biophysical Research Communications, 1980
- Peptide NeurotransmittersAnnual Review of Biochemistry, 1979
- Sequence of chicken ovalbumin mRNANature, 1978
- Empirical Predictions of Protein ConformationAnnual Review of Biochemistry, 1978
- Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteinsJournal of Molecular Biology, 1978
- A general method applicable to the search for similarities in the amino acid sequence of two proteinsJournal of Molecular Biology, 1970