FACTORS INFLUENCING THE RELEASE OF NORADRENALINE FROM HYPOTHALAMIC SLICES OF THE POSSUM, TRICHOSURUS VULPECULA
- 1 June 1984
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 62 (3) , 341-354
- https://doi.org/10.1038/icb.1984.34
Abstract
Slices of hypothalamus of the possum, Trichosurus vulpecula, were incubated with 3H noradrenaline and the subsequent spontaneous and K+ -induced effluxes of 3H measured. Unchanged 3H noradrenaline comprised virtually all the K+-induced efflux, indicating that there was little, if any, metabolism of the amine after its release. Receptor-modulation of the K+-induced efflux of 3H was shown by inhibition of this efflux by noradrenaline, clonidine, angiotensin II and leu-enkephalin, and by the increase in efflux produced by yohimbine and isoprenaline. It is concluded that, in the possum, the control of spontaneous and K+-induced release of noradrenaline in the hypothalamus is similar to that in eutherian mammalian brain.Keywords
This publication has 5 references indexed in Scilit:
- METABOLISM OF EXOGENOUS NORADRENALINE IN SLICES OF HYPOTHALAMUS AND CAUDATE NUCLEUS OF THE BRUSH‐TAIL POSSUM, TRICHOSURUS VULPECULAImmunology & Cell Biology, 1984
- Angiotensin II facilitates the potassium-evoked release of 3H-noradrenaline from the rabbit hypothalamusEuropean Journal of Pharmacology, 1979
- The rate constants for the efflux of the metabolites of noradrenaline from rabbit aortic stripsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1978
- Presynaptic receptor systems on the noradrenergic neurones of rat brainNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
- Metabolism of normetanephrine-H3 in rat brain—identification of conjugated 3-methoxy-4-hydrophenylglycol as the major metaboliteBiochemical Pharmacology, 1968