In vivo sites and cellular mechanisms of T reg cell–mediated suppression

Open Access

13 March 2006

journal article
editorial
Published by Rockefeller University Press in The Journal of Experimental Medicine

Vol. 203 (3) , 489-492
https://doi.org/10.1084/jem.20060214

Abstract

Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell–T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies.

Keywords

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