HEMODYNAMICS OF HYPERTHYROIDISM - EFFECTS OF AUTONOMIC NERVOUS BLOCKING AND ANTI-THYROID DRUG TREATMENT

  • 1 January 1976
    • journal article
    • research article
    • Vol. 17  (1) , 12-24
Abstract
Patients (7) with hyperthyroidism, diagnosed based on the determinations of BMR, 131I-uptake, T3[triiodothyronine]-resin sponge uptake (T3-RSU) and serum level of thyroxine (T4) were studied. The hemodynamic estimation was done at rest, after vagus blocking by the injection of 0.04 mg/kg b.wt. (body weight) atropine and 0.2 mg/kg b.wt. propranolol before (hyperthyroid state = H) and after (euthyroid state = E) antithyroid drug therapy. Cardiac output was measured by the dye-dilution method, and the value was calculated according to the standard Hamilton formula. The vagal tone is lower in H than in E. Sympathetic .beta.-receptor tone is higher in H than in E. The sympathetic .alpha.-receptor tone in H may be equivalent to that in E. There might exist inotropic factors which affect the hemodynamics, other than the autonomic nervous system in H.