Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution
Top Cited Papers
- 1 May 2007
- journal article
- review article
- Published by Springer Nature in Nature Clinical Practice Neurology
- Vol. 3 (5) , 256-263
- https://doi.org/10.1038/ncpneuro0490
Abstract
Cerebral vasospasm is the classic cause of delayed neurological deterioration after aneurysmal subarachnoid hemorrhage, leading to cerebral ischemia and infarction, and thus to poor outcome and occasionally death. Advances in diagnosis and treatment-principally the use of nimodipine, intensive care management, hemodynamic manipulations and endovascular neuroradiology procedures-have improved the prospects for these patients, but outcomes remain disappointing. Recent clinical trials have demonstrated marked prevention of vasospasm with the endothelin receptor antagonist clazosentan, yet patient outcome was not improved. This Review considers possible explanations for this result and proposes alternative causes of neurological deterioration and poor outcome after subarachnoid hemorrhage, including delayed effects of global cerebral ischemia, thromboembolism, microcirculatory dysfunction and cortical spreading depression.Keywords
This publication has 47 references indexed in Scilit:
- Transient Receptor Potential Channels of the Melastatin Family and Ischemic Responses of Central NeuronsStroke, 2007
- Prevention of Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage with Clazosentan, an Endothelin Receptor AntagonistNeurosurgery, 2006
- Threshold Duration of Ischemia for Myogenic Tone in Middle Cerebral ArteriesStroke, 2001
- Effects of S -Nitrosoglutathione on Acute Vasoconstriction and Glutamate Release After Subarachnoid HemorrhageStroke, 1999
- Functional Changes in Human Pial Arteries (300 to 900 μm ID) Within 48 Hours of Aneurysmal Subarachnoid HemorrhageStroke, 1998
- Case-Fatality Rates and Functional Outcome After Subarachnoid HemorrhageStroke, 1997
- Comparable Studies of the Incidence of Stroke and its Pathological TypesStroke, 1997
- Subarachnoid hemorrhage and endothelial L-arginine pathway in small brain stem arteries in dogs.Stroke, 1993
- Does vasospasm occur in small pial arteries and arterioles of rabbits?Stroke, 1991
- Effect of nimodipine on the outcome of patients after aneurysmal subarachnoid hemorrhage and surgeryJournal of Neurosurgery, 1988