Contrast media reactions: experimental evidence against the allergy theory

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Abstract
In order to clarify whether adverse reactions to radiographic contrast media may be allergic in nature, it is essential to show that contrast media can act as haptens and induce antibody formation n vivo. Experiments in Hooded Lister rats were carried out using techniques specifically designed to produce favorable conditions for the production of antibodies. No evidence of any antibody formation was found in any of the experiments. Radiographic contrast media in their native form apparently do not act as haptens, contrary to previously published data, and it therefore seems unlikely that the majority of adverse reactions to radiographic contrast media are allergic in nature.