"Influences" of Breast-Cancer Development in Mice

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Abstract
An attempt was made to coordinate the work on spontaneous and estrogenic induced breast cancer in mice. A theory was advanced assuming that there are 3 "influences" in breast cancer etiology. These were a "breast-cancer-producing influence" transmitted in the milk of potentially cancerous [female][female] a breast cancer susceptibility transmitted as a dominant complex; an ovarian or hormonal stimulation of the mammary tissue. Inherited breast cancer in mice would result from the simultaneous presence of these 3 "influences." Low tumor ratios resulted in mice lacking one or more.