The relationship between immunological parameters and response to therapy in resistant oral candidosis

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Abstract
Patients (8) with resistant oral candidal infection have undergone full immunological assessment. In 4 of these patients no significant abnormality of immune function was observed, and all responded to intensive antifungal therapy with nutritional supplements of iron and folic acid as required. The remaining 4 patients had abnormalities only of specific Candida-related immune function and no detectable abnormality of general immune function. Surgical excision of affected areas of oral mucosa was the most effective therapy in 3 of these 4 cases. The immunological findings in these cases are compared with those observed in 5 patients with chronic mucocutaneous candidosis in whom specific Candida-related and non-specific immune incompetence were present.

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