THE EFFECTS OF ALCOHOL OR OF THIAMINE DEFICIENCY UPON REPRODUCTION IN THE FEMALE RAT AND FETAL DEVELOPMENT
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Alcohol and Alcoholism
- Vol. 18 (1) , 45-51
- https://doi.org/10.1093/oxfordjournals.alcalc.a044335
Abstract
It has been found that a deficiency of thiamine alone has a more severe effect upon ovarian function and fertility than a high alcohol diet. This suggests that thiamine lack may account largely for the infertility associated with B-group vitamin deficiency and also that associated thiamine lack may play a part in the reduction of fertility associated with chronic alcoholism in women of child-bearing age. Litter size was reduced in animals fed alcohol (as 35% of total calories) but no fetal abnormalities were seen. Even after acute high-dose alcohol administration on the seventh day of gestation only slight craniofacial abnormalities possibly suggestive of the fetal alcohol syndrome were found.Keywords
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