Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder in Langer-Giedion syndrome
- 1 January 1993
- journal article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 64 (3-4) , 208-209
- https://doi.org/10.1159/000133577
Abstract
Fifteen cosmids containing sequences from the human bone moΦhogenetic protein 1 gene (BMPl) were isolated from a cosmid library. The probe was a 483-bp DNA obtained by the reverse transcriptase-PCR method using primers designed according to the reported BMP 1 sequence. When the positive cosmids were tested for chromosome fluorescence in situ hybridization, all showed signals at 8p21. The results indicated that BMPl is not responsible for Langer-Giedion syndrome, whose putative gene has been assigned to 8q24.Keywords
This publication has 0 references indexed in Scilit: