Biological fate and clinical implications of arginine metabolism in tissue healing
- 1 July 2006
- journal article
- review article
- Published by Wiley in Wound Repair and Regeneration
- Vol. 14 (4) , 376-386
- https://doi.org/10.1111/j.1743-6109.2006.00151.x
Abstract
Since its discovery in 1987, many biological roles (including wound healing) have been identified for nitric oxide (NO). The gas is produced by NO synthase using the dibasic amino acid L-arginine as a substrate. It has been established that a lack of dietary L-arginine delays experimental wound healing. Arginine can also be metabolized to urea and ornithine by arginase-1, a pathway that generates L-proline, a substrate for collagen synthesis, and polyamines, which stimulate cellular proliferation. Herein, we review subjects of interest in arginine metabolism, with emphasis on the biochemistry of wound NO production, relative NO synthase isoform activity in healing wounds, cellular contributions to NO production, and NO effects and mechanisms of action in wound healing.Keywords
This publication has 154 references indexed in Scilit:
- Early effects of exogenous arginine after the implantation of prosthetic material into the rat abdominal wallLife Sciences, 2000
- Keratinocyte-Derived Chemotactic Cytokines: Expressional Modulation by Nitric Oxide in Vitro and during Cutaneous Wound Repair in VivoBiochemical and Biophysical Research Communications, 2000
- Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial FunctionBiochemical and Biophysical Research Communications, 1999
- Inhibition of Nitric Oxide Synthesis in Wounds: Pharmacology and Effect on Accumulation of Collagen in Wounds in MiceBritish Journal of Surgery, 1999
- Regulation of Inducible Nitric Oxide Synthase mRNA Levels by Differentiation and Cytokines in Human KeratinocytesBiochemical and Biophysical Research Communications, 1996
- Nitric Oxide Regulates IL-8 Expression in Melanoma Cells at the Transcriptional LevelBiochemical and Biophysical Research Communications, 1995
- Arginase Induction by Suppressors of Nitric Oxide Synthesis (IL-4, IL-10 and PGE2) in Murine Bone-Marrow-Derived MacrophagesBiochemical and Biophysical Research Communications, 1995
- Nω-Hydroxy-L-Arginine, an Intermediate in the L-Arginine to Nitric Oxide Pathway, Is a Strong Inhibitor of Liver and Macrophage ArginaseBiochemical and Biophysical Research Communications, 1994
- Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophilsBiochemical and Biophysical Research Communications, 1992
- Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALBc 3T3 fibroblasts by a cyclic GMP-independent mechanismBiochemical and Biophysical Research Communications, 1990