Conformation-Dependent Sequence Design (Engineering) ofABCopolymers

A sequence design scheme to generate special primary structures in $\mathrm{AB}$ copolymers is proposed. In this scheme the type which is attributed to a given monomeric unit ( $A$ or $B$) depends on the spatial position of this unit in some “parent” homopolymer chain conformation. We consider two possible parent conformations: globular (giving rise to “proteinlike copolymers”) and adsorbed (generating “adsorption-tuned copolymers”). By means of the Monte Carlo simulations it is shown that the $\mathrm{AB}$ copolymers with specially generated sequences have the physical properties different from those for random $\mathrm{AB}$ copolymers, i.e., they “inherit” some features of the parent conformation.