Continuous 24-Hour Infusion of Folinic Acid Does Not Increase the Response Rate of 5-Fluorouracil but Only the Toxicity

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Abstract
Twenty-four patients with advanced colorectal cancer received two cycles of combination chemotherapy consisting of mitomycin 10 mg/m2 for 5 days continuous infusion and allopurinol 300 mg x 3/day p.o.for21 days. Two patients responded partially following the two cycles of chemotherapy. Additionally, all patients received folinic acid 200 mg/m2 for 5 days as a continuous infusion. None of the nonresponders responded to the addition of folinic acid, on the contrary toxicity was increased and 2 toxic deaths were reported. We conclude that continuous infusion of folinic acid added to the combination of mitomycin and 5-fluorouracil does not improve the response rate but onyl enhances toxicity.

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