Heparin Nebulization Attenuates Acute Lung Injury in Sepsis Following Smoke Inhalation in Sheep
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- 1 September 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Shock
- Vol. 18 (3) , 236-241
- https://doi.org/10.1097/00024382-200209000-00006
Abstract
Pseudomonas pneumonia is a common complication of smoke inhalation injury. Airway casts formed from clotted mucous occur frequently in this condition. A recent report shows that intravenous heparin improves oxygenation and reduces lung damage in a sheep model of smoke inhalation. We hypothesized that nebulized heparin could be an effective means of reducing cast formation. Female sheep (n = 19) were surgically prepared for a study of acute lung injury (ALI). After a tracheotomy, 48 breaths of cotton smoke (Pseudomonas aeruginosaKeywords
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