Osmotic Diuresis

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Abstract
IN recent years the widening application of osmotic diuretics in the practice of medicine has renewed interest in the physiologic effects of those agents. Mannitol is now prescribed in a wide variety of clinical settings, including drug intoxications, refractory edema, oliguric renal failure, and cerebral edema. Although the therapeutic value of mannitol in these settings remains controversial, its effect on body-fluid composition and volume is predictable and its administration can have important clinical consequences. Similarly, the contrast materials now used extensively in angiographic procedures can invoke an osmotic diuresis and alter body composition. In addition, osmotic diuresis is recognized as . . .

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