Stimulation of Progestin Release from Rabbit Ovary in vivo.

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Abstract
The ovarian veins of New Zealand white rabbits were cannulated and the blood assayed for progesterone derivatives by physico-chemical methods following chromatographic separation. The results reveal that 1) progesterone and its metabolite [DELTA]4-3-ketopregnene-20-ol are present in the ovarian vein blood of estrous rabbits without functional corpora lutea, 2) after mating or the administration of a gonadotropin which induces ovulation, the output of these steroids is immediately elevated, 3) gonadotropins, but not lactogenic hormone (LGH), also activate progestin release from the ovary containing functional corpora lutea of pregnancy or pseudopregnancy.

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