Impaired Development of Atherosclerosis in Hyperlipidemic Ldlr −/− and ApoE −/− Mice Transplanted With Abcg1 −/− Bone Marrow

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Abstract
Objective— The lungs of Abcg1−/− mice accumulate macrophage foam cells that contain high levels of unesterified and esterified cholesterol, consistent with a role for ABCG1 in facilitating the effl... Transplantation of Abcg1−/− bone marrow into Ldlr−/− or ApoE−/− mice reduced atherosclerosis. The lesions of Ldlr−/− mice transplanted with Abcg1−/− cells also contained increased numbers of apopto...