Dose-Dependent Effects of Fentanyl on Indomethacin-Induced Gastric Damage

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Abstract
Whilst developing a rat model for studies of gastric protection, we noticed that the anaesthetic agent ‘Hypnorm’, containing the opiate fentanyl 0.315 mg/ml and the butyrophenone fluanisone 10 mg/ml, was itself protective against indomethacin-induced damage: unrestrained animals given indomethacin (20 mg/kg) subcutaneously had an ulcer score of 9 ± 1 mm2, compared with 1 ± 1 mm2 in animals pre-treated with Hypnorm (0.8 ml/kg) and then given indomethacin (p 2; fentanyl, 18 μg/kg potentiated damage, 15 ± 4 mm2 (p 2 and 0.1 ± 0.1 mm2, respectively (p

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