Proteases in host cell invasion by the malaria parasite
- 1 October 2004
- journal article
- review article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 6 (10) , 893-903
- https://doi.org/10.1111/j.1462-5822.2004.00437.x
Abstract
The life cycle of the malaria parasite contains three distinct invasive forms, or zoites. For at least two of these--the sporozoite and the blood-stage merozoite--invasion into their respective host cell requires the activity of parasite proteases. This review summarizes the evidence for this, discusses selected well-described proteolytic modifications linked to invasion, and describes recent progress towards identifying the proteases involved.Keywords
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