Concise, Catalytic Asymmetric Synthesis of Tetrahydroisoquinoline- and Dihydroisoquinoline-3-carboxylic Acid Derivatives
- 1 January 2001
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2001 (11) , 1716-1718
- https://doi.org/10.1055/s-2001-16747
Abstract
Catalytic asymmetric synthesis of tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives 1 has been accomplished by the successful utilization of phase-transfer catalysis of the C 2-symmetric chiral quaternary ammonium bromides. Our approach also enables facile synthesis of quaternary isoquinoline derivatives 2 and 3 with high enantiomeric purities.Keywords
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